2kv4
From Proteopedia
(Difference between revisions)
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| - | + | ==EGF== | |
| - | ===EGF=== | + | <StructureSection load='2kv4' size='340' side='right' caption='[[2kv4]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2kv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KV4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kv4 RCSB], [http://www.ebi.ac.uk/pdbsum/2kv4 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human epidermal growth factor (hEGF) induces the proliferation, differentiation and survival of various cell types including tumor-derived cells. Generally, hEGF performs its biological function by binding to a specific receptor (hEGFR) on the cell surface, thereby inducing signal transduction. Suramin, a polysulfonated naphthylurea that acts as a growth factor blocker, exhibits antiproliferative activity against non-small cell lung cancer (NSCLC) cells that overexpress EGFR on the cell surface. We determined the solution structure of hEGF under physiological conditions and investigated the interaction of suramin with hEGF using isothermal titration calorimetry and NMR spectroscopy techniques. The solution structure of hEGF presented in this paper is different from the bound form of hEGF present in the crystal structure of the 2:2 EGF-EGFR complex because its C-tail contains a hydrophobic core. This conformational difference supports the hypothesis that hEGF undergoes a conformational change when it binds to hEGFR and subsequently induces signal transduction. Based on the docking structure of the hEGF-suramin complex, we demonstrated how suramin blocks hEGF by binding to its receptor binding site (the C-terminal region around Arg45) and inhibits the crucial conformational change. | ||
| - | + | The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin.,Huang HW, Mohan SK, Yu C Biochem Biophys Res Commun. 2010 Nov 26;402(4):705-10. Epub 2010 Oct 26. PMID:21029725<ref>PMID:21029725</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Epidermal growth factor|Epidermal growth factor]] | *[[Epidermal growth factor|Epidermal growth factor]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Huang, H W | + | [[Category: Huang, H W]] |
| - | [[Category: Mohan, S K | + | [[Category: Mohan, S K]] |
| - | [[Category: Yu, C | + | [[Category: Yu, C]] |
[[Category: Egf-like domain]] | [[Category: Egf-like domain]] | ||
[[Category: Epithermal growth factor]] | [[Category: Epithermal growth factor]] | ||
[[Category: Hormone]] | [[Category: Hormone]] | ||
Revision as of 11:17, 18 December 2014
EGF
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