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4asi

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{{STRUCTURE_4asi| PDB=4asi | SCENE= }}
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==Crystal structure of human ACACA C-terminal domain==
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===Crystal structure of human ACACA C-terminal domain===
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<StructureSection load='4asi' size='340' side='right' caption='[[4asi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[4asi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASI FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yl2|2yl2]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asi RCSB], [http://www.ebi.ac.uk/pdbsum/4asi PDBsum]</span></td></tr>
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==Function==
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</table>
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[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref>
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== Disease ==
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[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref>
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==About this Structure==
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== Function ==
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[[4asi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASI OCA].
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[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref>
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Delft, F Von.]]
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[[Category: Delft, F Von]]
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[[Category: Edwards, A.]]
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[[Category: Edwards, A]]
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[[Category: Froese, D S.]]
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[[Category: Froese, D S]]
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[[Category: Kiyani, W.]]
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[[Category: Kiyani, W]]
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[[Category: Krojer, T.]]
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[[Category: Krojer, T]]
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[[Category: Muniz, J R.C.]]
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[[Category: Muniz, J R.C]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann, U]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar, M]]
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[[Category: Yue, W W.]]
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[[Category: Yue, W W]]
[[Category: Ligase]]
[[Category: Ligase]]
[[Category: Protein]]
[[Category: Protein]]

Revision as of 09:28, 21 December 2014

Crystal structure of human ACACA C-terminal domain

4asi, resolution 2.80Å

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