4asi
From Proteopedia
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| - | + | ==Crystal structure of human ACACA C-terminal domain== | |
| - | + | <StructureSection load='4asi' size='340' side='right' caption='[[4asi]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[4asi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASI FirstGlance]. <br> |
| - | [[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yl2|2yl2]]</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asi RCSB], [http://www.ebi.ac.uk/pdbsum/4asi PDBsum]</span></td></tr> | |
| - | ==Function== | + | </table> |
| - | [[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | + | == Disease == |
| - | + | [[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | |
| - | == | + | == Function == |
| - | + | [[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Delft, F Von | + | [[Category: Delft, F Von]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Froese, D S | + | [[Category: Froese, D S]] |
| - | [[Category: Kiyani, W | + | [[Category: Kiyani, W]] |
| - | [[Category: Krojer, T | + | [[Category: Krojer, T]] |
| - | [[Category: Muniz, J R.C | + | [[Category: Muniz, J R.C]] |
| - | [[Category: Oppermann, U | + | [[Category: Oppermann, U]] |
| - | [[Category: Vollmar, M | + | [[Category: Vollmar, M]] |
| - | [[Category: Yue, W W | + | [[Category: Yue, W W]] |
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Protein]] | [[Category: Protein]] | ||
Revision as of 09:28, 21 December 2014
Crystal structure of human ACACA C-terminal domain
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Categories: Homo sapiens | Arrowsmith, C H | Bountra, C | Delft, F Von | Edwards, A | Froese, D S | Kiyani, W | Krojer, T | Muniz, J R.C | Oppermann, U | Vollmar, M | Yue, W W | Ligase | Protein
