3svf
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand== | |
| - | + | <StructureSection load='3svf' size='340' side='right' caption='[[3svf]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3svf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SVF FirstGlance]. <br> | |
| - | ==Disease== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WDR:(4S)-6-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-4-(2-HYDROXYETHOXY)-3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>WDR</scene></td></tr> |
| - | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3svg|3svg]], [[3svh|3svh]]</td></tr> |
| - | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |
| - | ==Function== | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3svf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3svf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3svf RCSB], [http://www.ebi.ac.uk/pdbsum/3svf PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | <references | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Felletar, I | + | [[Category: Felletar, I]] |
| - | [[Category: Filippakopoulos, P | + | [[Category: Filippakopoulos, P]] |
| - | [[Category: Knapp, S | + | [[Category: Knapp, S]] |
| - | [[Category: Picaud, S | + | [[Category: Picaud, S]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
[[Category: Bromodomain]] | [[Category: Bromodomain]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 06:51, 21 December 2014
Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand
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