2yt2
From Proteopedia
| Line 4: | Line 4: | ||
==Function== | ==Function== | ||
| - | [[http://www.uniprot.org/uniprot/FRS3_HUMAN FRS3_HUMAN]] Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.<ref>PMID:15094036</ref> | + | [[http://www.uniprot.org/uniprot/FRS3_HUMAN FRS3_HUMAN]] Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.<ref>PMID:15094036</ref> |
==About this Structure== | ==About this Structure== | ||
| - | [[2yt2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[2yt2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YT2 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020454865</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:020454865</ref><references group="xtra"/><references/> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Harada, T.]] | [[Category: Harada, T.]] | ||
[[Category: Kigawa, T.]] | [[Category: Kigawa, T.]] | ||
Revision as of 04:39, 13 February 2014
Contents |
Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK
Template:ABSTRACT PUBMED 20454865
Function
[FRS3_HUMAN] Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.[1]
About this Structure
2yt2 is a 1 chain structure with sequence from Human. Full experimental information is available from OCA.
Reference
- Koshiba S, Li H, Motoda Y, Tomizawa T, Kasai T, Tochio N, Yabuki T, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yamamoto T, Yokoyama S. Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2. J Struct Funct Genomics. 2010 May 8. PMID:20454865 doi:10.1007/s10969-010-9091-x
- ↑ Gotoh N, Laks S, Nakashima M, Lax I, Schlessinger J. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS Lett. 2004 Apr 23;564(1-2):14-8. PMID:15094036 doi:10.1016/S0014-5793(04)00287-X
Categories: Human | Harada, T. | Kigawa, T. | Koshiba, S. | Li, H. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Tomizawa, T. | Watanabe, S. | Yokoyama, S. | Chimera | Halk | National project on protein structural and functional analyse | Nppsfa | Ptb domain | Riken structural genomics/proteomics initiative | Rsgi | Signaling protein | Snt-2 | Structural genomic
