2d1l

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[[Image:2d1l.gif|left|200px]]<br /><applet load="2d1l" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2d1l.gif|left|200px]]
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caption="2d1l, resolution 1.85&Aring;" />
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'''Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)'''<br />
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{{Structure
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|PDB= 2d1l |SIZE=350|CAPTION= <scene name='initialview01'>2d1l</scene>, resolution 1.85&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= Mtss1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2D1L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1L OCA].
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2D1L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1L OCA].
==Reference==
==Reference==
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Structural basis for the actin-binding function of missing-in-metastasis., Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R, Structure. 2007 Feb;15(2):145-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17292833 17292833]
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Structural basis for the actin-binding function of missing-in-metastasis., Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R, Structure. 2007 Feb;15(2):145-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17292833 17292833]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: irsp53]]
[[Category: irsp53]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:54:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:22:11 2008''

Revision as of 14:22, 20 March 2008

Image:2d1l.gif


PDB ID 2d1l

Drag the structure with the mouse to rotate
, resolution 1.85Å
Gene: Mtss1 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)


Overview

The adaptor protein missing-in-metastasis (MIM) contains independent F- and G-actin binding domains, consisting, respectively, of an N-terminal 250 aa IRSp53/MIM homology domain (IMD) and a C-terminal WASP-homology domain 2 (WH2). We determined the crystal structures of MIM's IMD and that of its WH2 bound to actin. The IMD forms a dimer, with each subunit folded as an antiparallel three-helix bundle. This fold is related to that of the BAR domain. Like the BAR domain, the IMD has been implicated in membrane binding. Yet, comparison of the structures reveals that the membrane binding surfaces of the two domains have opposite curvatures, which may determine the type of curvature of the interacting membrane. The WH2 of MIM is longer than the prototypical WH2, interacting with all four subdomains of actin. We characterize a similar WH2 at the C terminus of IRSp53 and propose that in these two proteins WH2 performs a scaffolding function.

About this Structure

2D1L is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the actin-binding function of missing-in-metastasis., Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R, Structure. 2007 Feb;15(2):145-55. PMID:17292833

Page seeded by OCA on Thu Mar 20 16:22:11 2008

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