2d47

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[[Image:2d47.gif|left|200px]]<br /><applet load="2d47" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2d47.gif|left|200px]]
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caption="2d47, resolution 2.000&Aring;" />
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'''MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA'''<br />
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{{Structure
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|PDB= 2d47 |SIZE=350|CAPTION= <scene name='initialview01'>2d47</scene>, resolution 2.000&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2D47 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SPM:'>SPM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D47 OCA].
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2D47 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D47 OCA].
==Reference==
==Reference==
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Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1920437 1920437]
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Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1920437 1920437]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Aymami, J.]]
[[Category: Aymami, J.]]
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[[Category: double helix]]
[[Category: double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:55:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:23:07 2008''

Revision as of 14:23, 20 March 2008

Image:2d47.gif


PDB ID 2d47

Drag the structure with the mouse to rotate
, resolution 2.000Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA


Overview

We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences.

About this Structure

2D47 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:1920437

Page seeded by OCA on Thu Mar 20 16:23:07 2008

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