1gf2
From Proteopedia
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| - | + | ==TERTIARY STRUCTURES, RECEPTOR BINDING, AND ANTIGENICITY OF INSULINLIKE GROWTH FACTORS== | |
| + | <StructureSection load='1gf2' size='340' side='right' caption='[[1gf2]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GF2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gf2 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1gf2 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Three-dimensional models for human insulinlike growth factors (IGF-I and IGF-II) have been constructed by using interactive molecular graphics. It is suggested that the two growth factors have structures in which the A and B chains and the hydrophobic cores are identical to those of insulin. The conformations of the connecting peptides and COOH-terminal extensions are predicted by statistical methods but the structures are limited by the constraints implied by the insulinlike part. The models explain the nonsuppressibility by anti-insulin antibodies of the IGFs and show that part of the insulin receptor-binding region is conserved, which explains the growth factors' ability to bind insulin receptors. | ||
| - | + | Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.,Blundell TL, Bedarkar S, Humbel RE Fed Proc. 1983 Jun;42(9):2592-7. PMID:6189745<ref>PMID:6189745</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bedarkar, S]] | [[Category: Bedarkar, S]] | ||
[[Category: Blundell, T L]] | [[Category: Blundell, T L]] | ||
[[Category: Humbel, R E]] | [[Category: Humbel, R E]] | ||
Revision as of 12:36, 18 December 2014
TERTIARY STRUCTURES, RECEPTOR BINDING, AND ANTIGENICITY OF INSULINLIKE GROWTH FACTORS
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