This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ugv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_1ugv| PDB=1ugv | SCENE= }}
+
==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)==
-
===Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)===
+
<StructureSection load='1ugv' size='340' side='right' caption='[[1ugv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
 
+
== Structural highlights ==
-
==Disease==
+
<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA hg04539 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [http://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [http://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
 +
<table>
 +
== Disease ==
[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
-
 
+
== Function ==
-
==Function==
+
[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] GTPase-activating protein for RHOA and CDC42.
[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] GTPase-activating protein for RHOA and CDC42.
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[1ugv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA].
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aoki, M.]]
[[Category: Aoki, M.]]

Revision as of 21:44, 29 September 2014

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ugv"
Views
Personal tools
Navigation
Toolbox