4jib

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'''Unreleased structure'''
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{{STRUCTURE_4jib| PDB=4jib | SCENE= }}
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===Crystal structure of of PDE2-inhibitor complex===
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{{ABSTRACT_PUBMED_23582272}}
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The entry 4jib is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN]] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
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Authors: Pandit, J.
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==About this Structure==
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[[4jib]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIB OCA].
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Description: Crystal structure of of PDE2-inhibitor complex
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==Reference==
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<references group="xtra"/><references/>
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Pandit, J.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 07:36, 2 May 2013

Template:STRUCTURE 4jib

Contents

Crystal structure of of PDE2-inhibitor complex

Template:ABSTRACT PUBMED 23582272

Function

[PDE2A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.[1] [2]

About this Structure

4jib is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Iffland A, Kohls D, Low S, Luan J, Zhang Y, Kothe M, Cao Q, Kamath AV, Ding YH, Ellenberger T. Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. Biochemistry. 2005 Jun 14;44(23):8312-25. PMID:15938621 doi:10.1021/bi047313h
  2. ↑ Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc Natl Acad Sci U S A. 2009 Oct 14. PMID:19828435

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