4f6p

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{{STRUCTURE_4f6p| PDB=4f6p | SCENE= }}
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==Crystal structure of the yeast metacaspase Yca1 C276A mutant==
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===Crystal structure of the yeast metacaspase Yca1 C276A mutant===
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<StructureSection load='4f6p' size='340' side='right' caption='[[4f6p]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4f6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F6P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DFH:1,1-DIPHENYLETHANOL'>DFH</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f6o|4f6o]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCA1, YCA1, YOR197W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f6p RCSB], [http://www.ebi.ac.uk/pdbsum/4f6p PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MCA1_YEAST MCA1_YEAST]] Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging. Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells. Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa. Promotes the removal of insoluble protein aggregates during normal growth.<ref>PMID:11983181</ref> <ref>PMID:15489197</ref> <ref>PMID:15381687</ref> <ref>PMID:14970189</ref> <ref>PMID:14718573</ref> <ref>PMID:16170310</ref> <ref>PMID:15668299</ref> <ref>PMID:15939758</ref> <ref>PMID:16079294</ref> <ref>PMID:16301538</ref> <ref>PMID:20624963</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/MCA1_YEAST MCA1_YEAST]] Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging. Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells. Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa. Promotes the removal of insoluble protein aggregates during normal growth.<ref>PMID:11983181</ref><ref>PMID:15489197</ref><ref>PMID:15381687</ref><ref>PMID:14970189</ref><ref>PMID:14718573</ref><ref>PMID:16170310</ref><ref>PMID:15668299</ref><ref>PMID:15939758</ref><ref>PMID:16079294</ref><ref>PMID:16301538</ref><ref>PMID:20624963</ref>
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*[[Caspase|Caspase]]
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== References ==
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==About this Structure==
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<references/>
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[[4f6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F6P OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Shi, Y G.]]
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[[Category: Shi, Y G]]
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[[Category: Wong, A H.]]
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[[Category: Wong, A H]]
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[[Category: Yan, C Y.]]
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[[Category: Yan, C Y]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Metacaspase]]
[[Category: Metacaspase]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]

Revision as of 14:46, 24 December 2014

Crystal structure of the yeast metacaspase Yca1 C276A mutant

4f6p, resolution 1.62Å

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