3jv3

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Template:STRUCTURE 3jv3

Contents

Structure of SH3E-DH unit of murine intersectin-1L

Template:ABSTRACT PUBMED 20585582

Function

[ITSN1_MOUSE] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1.

About this Structure

3jv3 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Ahmad KF, Lim WA. The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One. 2010 Jun 24;5(6):e11291. PMID:20585582 doi:10.1371/journal.pone.0011291

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OCA

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