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3juv
From Proteopedia
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| - | + | ==Crystal structure of human lanosterol 14alpha-demethylase (CYP51)== | |
| - | + | <StructureSection load='3juv' size='340' side='right' caption='[[3juv]], [[Resolution|resolution]] 3.12Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3juv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUV FirstGlance]. <br> | |
| - | == | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i3k|3i3k]], [[3jus|3jus]]</td></tr> |
| - | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |
| - | == | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr> |
| - | [[3juv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUV OCA]. | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3juv RCSB], [http://www.ebi.ac.uk/pdbsum/3juv PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3juv_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Sterol 14-demethylase]] | [[Category: Sterol 14-demethylase]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: MacKenzie, F | + | [[Category: MacKenzie, F]] |
| - | [[Category: Park, H | + | [[Category: Park, H]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Strushkevich, N | + | [[Category: Strushkevich, N]] |
| - | [[Category: Usanov, S A | + | [[Category: Usanov, S A]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
[[Category: Cholesterol biosynthesis]] | [[Category: Cholesterol biosynthesis]] | ||
[[Category: Cytochrome p450]] | [[Category: Cytochrome p450]] | ||
| Line 38: | Line 48: | ||
[[Category: Sterol 14alpha-demethylase]] | [[Category: Sterol 14alpha-demethylase]] | ||
[[Category: Sterol biosynthesis]] | [[Category: Sterol biosynthesis]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
Revision as of 15:18, 18 December 2014
Crystal structure of human lanosterol 14alpha-demethylase (CYP51)
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Categories: Homo sapiens | Sterol 14-demethylase | Arrowsmith, C H | Bountra, C | Edwards, A M | MacKenzie, F | Park, H | Structural genomic | Strushkevich, N | Usanov, S A | Weigelt, J | Cholesterol biosynthesis | Cytochrome p450 | Endoplasmic reticulum | Heme | Iron | Lipid synthesis | Membrane | Metal-binding | Microsome | Monooxygenase | Nadp | Oxidoreductase | Sgc | Steroid biosynthesis | Sterol 14alpha-demethylase | Sterol biosynthesis | Transmembrane
