3jrn

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{{STRUCTURE_3jrn| PDB=3jrn | SCENE= }}
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==Crystal structure of TIR domain from Arabidopsis Thaliana==
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===Crystal structure of TIR domain from Arabidopsis Thaliana===
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<StructureSection load='3jrn' size='340' side='right' caption='[[3jrn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19845004}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3jrn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JRN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AT1G72930, At1g72930/F3N23.13, AtTIR, F3N23.13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jrn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jrn RCSB], [http://www.ebi.ac.uk/pdbsum/3jrn PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/3jrn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Plants use a highly evolved immune system to exhibit defense response against microbial infections. The plant TIR domain, together with the nucleotide-binding (NB) domain and/or a LRR region, forms a type of molecule, named resistance (R) proteins, that interact with microbial effector proteins and elicit hypersensitive responses against infection. Here, we report the first crystal structure of a plant TIR domain from Arabidopsis thaliana (AtTIR) solved at a resolution of 2.0 A. The structure consists of five beta-strands forming a parallel beta-sheet at the core of the protein. The beta-strands are connected by a series of alpha-helices and the overall fold mimics closely that of other mammalian and bacterial TIR domains. However, the region of the alphaD-helix reveals significant differences when compared with other TIR structures, especially the alphaD3-helix that corresponds to an insertion only present in plant TIR domains. Available mutagenesis data suggest that several conserved and exposed residues in this region are involved in the plant TIR signaling function.
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==About this Structure==
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The crystal structure of a TIR domain from Arabidopsis thaliana reveals a conserved helical region unique to plants.,Chan SL, Mukasa T, Santelli E, Low LY, Pascual J Protein Sci. 2010 Jan;19(1):155-61. PMID:19845004<ref>PMID:19845004</ref>
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[[3jrn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRN OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:019845004</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Chan, S L.]]
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[[Category: Chan, S L]]
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[[Category: Low, L Y.]]
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[[Category: Low, L Y]]
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[[Category: Mukasa, T.]]
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[[Category: Mukasa, T]]
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[[Category: Pascual, J.]]
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[[Category: Pascual, J]]
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[[Category: Santelli, E.]]
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[[Category: Santelli, E]]
[[Category: Plant protein]]
[[Category: Plant protein]]
[[Category: Tir domain arabidopsis thaliana]]
[[Category: Tir domain arabidopsis thaliana]]

Revision as of 15:00, 18 December 2014

Crystal structure of TIR domain from Arabidopsis Thaliana

3jrn, resolution 2.00Å

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