3ipz

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{{STRUCTURE_3ipz| PDB=3ipz | SCENE= }}
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==Crystal structure of Arabidopsis monothiol glutaredoxin AtGRXcp==
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===Crystal structure of Arabidopsis monothiol glutaredoxin AtGRXcp===
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<StructureSection load='3ipz' size='340' side='right' caption='[[3ipz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20516625}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ipz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IPZ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRXS14, CXIP1, At3g54900, F28P10.120 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ipz RCSB], [http://www.ebi.ac.uk/pdbsum/3ipz PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Monothiol glutaredoxins (Grxs) play important roles in maintaining redox homeostasis in living cells and are conserved across species. Arabidopsis thaliana monothiol glutaredoxin AtGRXcp is critical for protection from oxidative stress in chloroplasts. The crystal structure of AtGRXcp has been determined at 2.4 A resolution. AtGRXcp has a glutaredoxin/thioredoxin-like fold with distinct structural features that differ from those of dithiol Grxs. The structure reveals that the putative active-site motif CGFS is well defined and is located on the molecular surface and that a long groove extends to both sides of the catalytic Cys97. Structural comparison and molecular modeling suggest that glutathione can bind in this groove and form extensive interactions with conserved charged residues including Lys89, Arg126 and Asp152. Further comparative studies reveal that a unique loop with five additional residues adjacent to the active-site motif may be a key structural feature of monothiol Grxs and may influence their function. This study provides the first structural information on plant CGFS-type monothiol Grxs, allowing a better understanding of the redox-regulation mechanism mediated by these plant Grxs.
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==Function==
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Structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp.,Li L, Cheng N, Hirschi KD, Wang X Acta Crystallogr D Biol Crystallogr. 2010 Jun;66(Pt 6):725-32. Epub 2010, May 15. PMID:20516625<ref>PMID:20516625</ref>
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[[http://www.uniprot.org/uniprot/GRS14_ARATH GRS14_ARATH]] May only reduce GSH-thiol disulfides, but not protein disulfides (Potential). May protect cells against protein oxidative damage. May regulate CAX cation transporters.<ref>PMID:16829529</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3ipz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPZ OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020516625</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Cheng, N.]]
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[[Category: Cheng, N]]
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[[Category: Li, L.]]
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[[Category: Li, L]]
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[[Category: Wang, X.]]
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[[Category: Wang, X]]
[[Category: Chloroplast]]
[[Category: Chloroplast]]
[[Category: Electron transport]]
[[Category: Electron transport]]

Revision as of 16:24, 18 December 2014

Crystal structure of Arabidopsis monothiol glutaredoxin AtGRXcp

3ipz, resolution 2.40Å

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