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3ip4

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Template:STRUCTURE 3ip4

Contents

The high resolution structure of GatCAB

Template:ABSTRACT PUBMED 19906721

Function

[GATA_STAAM] Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity). [GATC_STAAM] Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity). [GATB_STAAM] Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).

About this Structure

3ip4 is a 3 chain structure with sequence from Staphylococcus aureus subsp. aureus. Full crystallographic information is available from OCA.

Reference

  • Nakamura A, Sheppard K, Yamane J, Yao M, Soll D, Tanaka I. Two distinct regions in Staphylococcus aureus GatCAB guarantee accurate tRNA recognition. Nucleic Acids Res. 2010 Jan;38(2):672-82. Epub 2009 Nov 11. PMID:19906721 doi:10.1093/nar/gkp955
  • Ito T, Yokoyama S. Two enzymes bound to one transfer RNA assume alternative conformations for consecutive reactions. Nature. 2010 Sep 30;467(7315):612-6. PMID:20882017 doi:10.1038/nature09411

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OCA

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