3vfk
From Proteopedia
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{{STRUCTURE_3vfk| PDB=3vfk | SCENE= }} | {{STRUCTURE_3vfk| PDB=3vfk | SCENE= }} | ||
===The structure of monodechloro-teicoplanin in complex with its ligand, using ubiquitin as a ligand carrier=== | ===The structure of monodechloro-teicoplanin in complex with its ligand, using ubiquitin as a ligand carrier=== | ||
| + | {{ABSTRACT_PUBMED_23519660}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:023519660</ref><references group="xtra"/><references/> |
[[Category: Actinoplanes teichomyceticus]] | [[Category: Actinoplanes teichomyceticus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 08:36, 19 June 2013
Contents |
The structure of monodechloro-teicoplanin in complex with its ligand, using ubiquitin as a ligand carrier
Template:ABSTRACT PUBMED 23519660
Function
[UBC_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.[1] [2]
About this Structure
3vfk is a 2 chain structure with sequence from Actinoplanes teichomyceticus and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Economou NJ, Zentner IJ, Lazo E, Jakoncic J, Stojanoff V, Weeks SD, Grasty KC, Cocklin S, Loll PJ. Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach. Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):520-33. doi:, 10.1107/S0907444912050469. Epub 2013 Mar 14. PMID:23519660 doi:10.1107/S0907444912050469
- ↑ Huang F, Kirkpatrick D, Jiang X, Gygi S, Sorkin A. Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell. 2006 Mar 17;21(6):737-48. PMID:16543144 doi:S1097-2765(06)00120-1
- ↑ Komander D. The emerging complexity of protein ubiquitination. Biochem Soc Trans. 2009 Oct;37(Pt 5):937-53. doi: 10.1042/BST0370937. PMID:19754430 doi:10.1042/BST0370937
