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4isk

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4isk| PDB=4isk | SCENE= }}
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===Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor===
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{{ABSTRACT_PUBMED_23710599}}
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The entry 4isk is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI]] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
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Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.
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==About this Structure==
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[[4isk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISK OCA].
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Description: Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor
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==Reference==
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<ref group="xtra">PMID:023710599</ref><references group="xtra"/><references/>
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[[Category: Thymidylate synthase]]
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[[Category: Finer-Moore, J.]]
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[[Category: Stroud, R M.]]
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[[Category: Tochowicz, A.]]
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[[Category: Alpha/beta protein]]
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[[Category: Dump subtrate]]
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[[Category: Methylase]]
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[[Category: Methyltransferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 10:17, 25 December 2013

Template:STRUCTURE 4isk

Contents

Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor

Template:ABSTRACT PUBMED 23710599

Function

[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.

About this Structure

4isk is a 8 chain structure. Full crystallographic information is available from OCA.

Reference

  • Tochowicz A, Dalziel S, Eidam O, O'Connell JD 3rd, Griner S, Finer-Moore JS, Stroud RM. Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta [g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells. J Med Chem. 2013 Jun 21. PMID:23710599 doi:http://dx.doi.org/10.1021/jm400490e

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OCA

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