4j74

(Difference between revisions)

Revision as of 20:53, 7 August 2013

[MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

4j74 is a 1 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8. Epub 2004 Jan 2. PMID:14704432 doi:10.1126/science.1092472

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-'''Unreleased structure'''
+{{STRUCTURE_4j74|  PDB=4j74  |  SCENE=  }}
+===The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment===
+{{ABSTRACT_PUBMED_14704432}}
-The entry 4j74 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
-Authors: Janson, C., Lukacs, C., Kammlott, U., Graves, B.
+==About this Structure==
+[[4j74]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J74 OCA].
-Description: The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 -a nutlin fragment
+==Reference==
+<ref group="xtra">PMID:014704432</ref><references group="xtra"/><references/>
+[[Category: Xenopus laevis]]
+[[Category: Graves, B.]]
+[[Category: Janson, C.]]
+[[Category: Kammlott, U.]]
+[[Category: Lukacs, C.]]
+[[Category: E3 ubiquitin ligase]]
+[[Category: Imidazoline]]
+[[Category: Ligase-antagonist complex]]
+[[Category: Mdm2]]
+[[Category: Nucleus]]
+[[Category: P53]]