4jm0

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'''Unreleased structure'''
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{{STRUCTURE_4jm0| PDB=4jm0 | SCENE= }}
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===Structure of Human Cytomegalovirus Immune Modulator UL141===
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The entry 4jm0 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/UL141_HCMVM UL141_HCMVM]] Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand PVRL2/Nectin-2 for proteasome-mediated degradation.<ref>PMID:20410314</ref>
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Authors: Nemcovicova, I., Zajonc, D.M.
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==About this Structure==
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[[4jm0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JM0 OCA].
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Description: Structure of Human Cytomegalovirus Immune Modulator UL141
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Nemcovicova, I.]]
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[[Category: Zajonc, D M.]]
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[[Category: Cd155]]
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[[Category: Cell adhesion]]
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[[Category: Glycosylation]]
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[[Category: Host-virus interaction]]
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[[Category: Ig-like beta sandwich domain]]
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[[Category: Immunoglobulin-like v-set folg of n-terminal domain]]
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[[Category: Membrane]]
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[[Category: Trail-r2]]
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[[Category: Viral immunomodulator]]
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[[Category: Viral protein in complex with human receptor]]

Revision as of 18:21, 3 March 2014

Template:STRUCTURE 4jm0

Contents

Structure of Human Cytomegalovirus Immune Modulator UL141

Function

[UL141_HCMVM] Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand PVRL2/Nectin-2 for proteasome-mediated degradation.[1]

About this Structure

4jm0 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Prod'homme V, Sugrue DM, Stanton RJ, Nomoto A, Davies J, Rickards CR, Cochrane D, Moore M, Wilkinson GW, Tomasec P. Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112. J Gen Virol. 2010 Aug;91(Pt 8):2034-9. doi: 10.1099/vir.0.021931-0. Epub 2010 Apr, 21. PMID:20410314 doi:http://dx.doi.org/10.1099/vir.0.021931-0

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OCA

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