4jqf

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'''Unreleased structure'''
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{{STRUCTURE_4jqf| PDB=4jqf | SCENE= }}
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===Structure of the C-terminal domain of human telomeric Stn1===
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The entry 4jqf is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/STN1_HUMAN STN1_HUMAN]] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.<ref>PMID:19854130</ref> <ref>PMID:19648609</ref>
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Authors: Bryan, C.F., Rice, C.T., Harkisheimer, M., Schultz, D., Skordalakes, E.
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==About this Structure==
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[[4jqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQF OCA].
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Description: Structure of the C-terminal domain of human telomeric Stn1
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Bryan, C F.]]
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[[Category: Harkisheimer, M.]]
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[[Category: Rice, C T.]]
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[[Category: Schultz, D.]]
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[[Category: Skordalakes, E.]]
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[[Category: Ctc1]]
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[[Category: Dna binding protein]]
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[[Category: Pol alpha]]
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[[Category: Protein binding]]

Revision as of 18:15, 19 June 2013

Template:STRUCTURE 4jqf

Contents

Structure of the C-terminal domain of human telomeric Stn1

Function

[STN1_HUMAN] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.[1] [2]

About this Structure

4jqf is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Miyake Y, Nakamura M, Nabetani A, Shimamura S, Tamura M, Yonehara S, Saito M, Ishikawa F. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell. 2009 Oct 23;36(2):193-206. PMID:19854130 doi:S1097-2765(09)00587-5
  2. ↑ Wan M, Qin J, Songyang Z, Liu D. OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J Biol Chem. 2009 Sep 25;284(39):26725-31. Epub 2009 Aug 1. PMID:19648609 doi:M109.021105

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