4jwm

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m (Protected "4jwm" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4jwm| PDB=4jwm | SCENE= }}
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===Ternary complex of D256E mutant of DNA Polymerase Beta===
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{{ABSTRACT_PUBMED_23647366}}
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The entry 4jwm is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
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Authors: Batra, V.K., Perera, L., Ping, L., Shock, D.D., Beard, W.A., Pedersen, L.C., Pedersen, L.G., Wilson, S.H.
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==About this Structure==
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[[4jwm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JWM OCA].
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Description: Ternary complex of D256E mutant of DNA Polymerase Beta
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==Reference==
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<ref group="xtra">PMID:023647366</ref><references group="xtra"/><references/>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Homo sapiens]]
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[[Category: Batra, V K.]]
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[[Category: Beard, W A.]]
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[[Category: Pedersen, L C.]]
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[[Category: Pedersen, L G.]]
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[[Category: Perera, L.]]
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[[Category: Ping, L.]]
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[[Category: Shock, D D.]]
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[[Category: Wilson, S H.]]
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[[Category: Dntp]]
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[[Category: Non-hydrolyzable analog]]
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[[Category: Nucleotidyl transfer]]
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[[Category: Transferase-dna complex]]

Revision as of 09:51, 30 June 2013

Template:STRUCTURE 4jwm

Contents

Ternary complex of D256E mutant of DNA Polymerase Beta

Template:ABSTRACT PUBMED 23647366

Function

[DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.[1] [2] [3] [4]

About this Structure

4jwm is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Batra VK, Perera L, Lin P, Shock DD, Beard WA, Pedersen LC, Pedersen LG, Wilson SH. Amino Acid Substitution in the Active Site of DNA Polymerase beta Explains the Energy Barrier of the Nucleotidyl Transfer Reaction. J Am Chem Soc. 2013 May 29;135(21):8078-88. doi: 10.1021/ja403842j. Epub 2013 May, 16. PMID:23647366 doi:10.1021/ja403842j
  1. ↑ Bennett RA, Wilson DM 3rd, Wong D, Demple B. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7166-9. PMID:9207062
  2. ↑ Matsumoto Y, Kim K, Katz DS, Feng JA. Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups. Biochemistry. 1998 May 5;37(18):6456-64. PMID:9572863 doi:10.1021/bi9727545
  3. ↑ DeMott MS, Beyret E, Wong D, Bales BC, Hwang JT, Greenberg MM, Demple B. Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. J Biol Chem. 2002 Mar 8;277(10):7637-40. Epub 2002 Jan 22. PMID:11805079 doi:10.1074/jbc.C100577200
  4. ↑ Parsons JL, Dianova II, Khoronenkova SV, Edelmann MJ, Kessler BM, Dianov GL. USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta. Mol Cell. 2011 Mar 4;41(5):609-15. doi: 10.1016/j.molcel.2011.02.016. PMID:21362556 doi:10.1016/j.molcel.2011.02.016

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