1l3x

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==About this Structure==
==About this Structure==
[[1l3x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_brevicaudus Gloydius brevicaudus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1iq2 1iq2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3X OCA].
[[1l3x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_brevicaudus Gloydius brevicaudus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1iq2 1iq2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3X OCA].
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==See Also==
 
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*[[Disintegrin|Disintegrin]]
 
==Reference==
==Reference==

Revision as of 13:55, 19 June 2013

Template:STRUCTURE 1l3x

Contents

Solution Structure of Novel Disintegrin Salmosin

Template:ABSTRACT PUBMED 14661951

Function

[VM2HS_GLOBR] Metalloproteinase hxl-1: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).[1] [2] [3] [4] [5] Disintegrin salmosin-1: inhibits GPIIb/GPIIIa (ITGA2B/ITGB3) binding to immobilized fibrinogen with an IC(50) of 2.2 nM and ADP-induced platelet aggregation with an IC(50) of 131 nM, respectively. Inhibits angiogenesis.[6] [7] [8] [9] [10]

About this Structure

1l3x is a 1 chain structure with sequence from Gloydius brevicaudus. This structure supersedes the now removed PDB entry 1iq2. Full experimental information is available from OCA.

Reference

  • Shin J, Hong SY, Chung K, Kang I, Jang Y, Kim DS, Lee W. Solution structure of a novel disintegrin, salmosin, from Agkistrondon halys venom. Biochemistry. 2003 Dec 16;42(49):14408-15. PMID:14661951 doi:10.1021/bi0300276
  1. ↑ Kang IC, Chung KH, Lee SJ, Yun Y, Moon HM, Kim DS. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb Res. 1998 Jul 15;91(2):65-73. PMID:9722022
  2. ↑ Park D, Kang I, Kim H, Chung K, Kim DS, Yun Y. Cloning and characterization of novel disintegrins from Agkistrodon halys venom. Mol Cells. 1998 Oct 31;8(5):578-84. PMID:9856345
  3. ↑ Kang IC, Lee YD, Kim DS. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 1999 Aug 1;59(15):3754-60. PMID:10446992
  4. ↑ Kang IC, Kim DS, Jang Y, Chung KH. Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis. Biochem Biophys Res Commun. 2000 Aug 18;275(1):169-73. PMID:10944460 doi:10.1006/bbrc.2000.3130
  5. ↑ Kim SI, Kim KS, Kim HS, Choi MM, Kim DS, Chung KH, Park YS. Inhibition of angiogenesis by salmosin expressed in vitro. Oncol Res. 2004;14(4-5):227-33. PMID:14977354
  6. ↑ Kang IC, Chung KH, Lee SJ, Yun Y, Moon HM, Kim DS. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb Res. 1998 Jul 15;91(2):65-73. PMID:9722022
  7. ↑ Park D, Kang I, Kim H, Chung K, Kim DS, Yun Y. Cloning and characterization of novel disintegrins from Agkistrodon halys venom. Mol Cells. 1998 Oct 31;8(5):578-84. PMID:9856345
  8. ↑ Kang IC, Lee YD, Kim DS. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 1999 Aug 1;59(15):3754-60. PMID:10446992
  9. ↑ Kang IC, Kim DS, Jang Y, Chung KH. Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis. Biochem Biophys Res Commun. 2000 Aug 18;275(1):169-73. PMID:10944460 doi:10.1006/bbrc.2000.3130
  10. ↑ Kim SI, Kim KS, Kim HS, Choi MM, Kim DS, Chung KH, Park YS. Inhibition of angiogenesis by salmosin expressed in vitro. Oncol Res. 2004;14(4-5):227-33. PMID:14977354

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