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4j1b

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{{STRUCTURE_4j1b| PDB=4j1b | SCENE= }}
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==X-ray structure of the adduct between hen egg white lysozyme and AziRu (black crystal)==
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===X-ray structure of the adduct between hen egg white lysozyme and AziRu (black crystal)===
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<StructureSection load='4j1b' size='340' side='right' caption='[[4j1b]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23517183}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j1b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1B FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j1a|4j1a]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j1b RCSB], [http://www.ebi.ac.uk/pdbsum/4j1b PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy. The data provide clear evidence on the mechanism of AziRu-protein adduct formation and of ligand exchange in the crystal state.
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Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu.,Vergara A, D'Errico G, Montesarchio D, Mangiapia G, Paduano L, Merlino A Inorg Chem. 2013 Mar 22. PMID:23517183<ref>PMID:23517183</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4j1b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1B OCA].
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</div>
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==Reference==
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==See Also==
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<references group="xtra"/><references/>
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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[[Category: Gallus gallus]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chick]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
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[[Category: Merlino, A.]]
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[[Category: Merlino, A]]
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[[Category: Vergara, A.]]
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[[Category: Vergara, A]]
[[Category: C-type lysozyme/alpha-lactalbumin family]]
[[Category: C-type lysozyme/alpha-lactalbumin family]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 21:49, 25 December 2014

X-ray structure of the adduct between hen egg white lysozyme and AziRu (black crystal)

4j1b, resolution 1.66Å

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