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2duv
From Proteopedia
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| - | [[Image:2duv.jpg|left|200px]] | + | [[Image:2duv.jpg|left|200px]] |
| - | + | ||
| - | '''Structure of CDK2 with a 3-hydroxychromones''' | + | {{Structure |
| + | |PDB= 2duv |SIZE=350|CAPTION= <scene name='initialview01'>2duv</scene>, resolution 2.2Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=371:2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE'>371</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Structure of CDK2 with a 3-hydroxychromones''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2DUV is a [ | + | 2DUV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUV OCA]. |
==Reference== | ==Reference== | ||
| - | 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:[http:// | + | 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17178224 17178224] |
[[Category: Cyclin-dependent kinase]] | [[Category: Cyclin-dependent kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 24: | Line 33: | ||
[[Category: serine/threonine-protein kinase]] | [[Category: serine/threonine-protein kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:31:54 2008'' |
Revision as of 14:31, 20 March 2008
| |||||||
| , resolution 2.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Cyclin-dependent kinase, with EC number 2.7.11.22 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of CDK2 with a 3-hydroxychromones
Overview
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
About this Structure
2DUV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224
Page seeded by OCA on Thu Mar 20 16:31:54 2008
