2axm
From Proteopedia
(New page: 200px<br /> <applet load="2axm" size="450" color="white" frame="true" align="right" spinBox="true" caption="2axm, resolution 3.0Å" /> '''HEPARIN-LINKED BIOLO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2AXM is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AXM OCA]]. | + | 2AXM is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Structure known Active Sites: HPA and HPB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AXM OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: human acidic fibroblast growth factor]] | [[Category: human acidic fibroblast growth factor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:37:06 2007'' |
Revision as of 06:32, 30 October 2007
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HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
Overview
The fibroblast growth factors (FGFs) form a large family of structurally, related, multifunctional proteins that regulate various biological, responses. They mediate cellular functions by binding to transmembrane FGF, receptors, which are protein tyrosine kinases. FGF receptors are activated, by oligomerization, and both this activation and FGF-stimulated biological, responses require heparin-like molecules as well as FGF. Heparins are, linear anionic polysaccharide chains; they are typically heterogeneously, sulphated on alternating L-iduronic and D-glucosamino sugars, and are, nearly ubiquitous in animal tissues as heparan sulphate proteoglycans on, cell surfaces and in the extracellular matrix. Although several crystal, structures have been described for FGF molecules in complexes ... [(full description)]
About this Structure
2AXM is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Sites: HPA and HPB. Full crystallographic information is available from [OCA].
Reference
Structure of a heparin-linked biologically active dimer of fibroblast growth factor., DiGabriele AD, Lax I, Chen DI, Svahn CM, Jaye M, Schlessinger J, Hendrickson WA, Nature. 1998 Jun 25;393(6687):812-7. PMID:9655399
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