4ibx
From Proteopedia
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{{STRUCTURE_4ibx| PDB=4ibx | SCENE= }} | {{STRUCTURE_4ibx| PDB=4ibx | SCENE= }} | ||
===Crystal structure of stabilized TEM-1 beta-lactamase variant v.13=== | ===Crystal structure of stabilized TEM-1 beta-lactamase variant v.13=== | ||
| + | {{ABSTRACT_PUBMED_23542341}} | ||
==Function== | ==Function== | ||
Revision as of 19:30, 17 April 2013
Crystal structure of stabilized TEM-1 beta-lactamase variant v.13
Template:ABSTRACT PUBMED 23542341
Function
[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
About this Structure
4ibx is a 5 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
