2dwv
From Proteopedia
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| - | [[Image:2dwv.jpg|left|200px]] | + | [[Image:2dwv.jpg|left|200px]] |
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| - | '''Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)''' | + | {{Structure |
| + | |PDB= 2dwv |SIZE=350|CAPTION= <scene name='initialview01'>2dwv</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= Sav1, Ww45, Wwp3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2DWV is a [ | + | 2DWV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWV OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of an atypical WW domain in a novel beta-clam-like dimeric form., Ohnishi S, Guntert P, Koshiba S, Tomizawa T, Akasaka R, Tochio N, Sato M, Inoue M, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yokoyama S, FEBS Lett. 2007 Feb 6;581(3):462-8. Epub 2007 Jan 16. PMID:[http:// | + | Solution structure of an atypical WW domain in a novel beta-clam-like dimeric form., Ohnishi S, Guntert P, Koshiba S, Tomizawa T, Akasaka R, Tochio N, Sato M, Inoue M, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yokoyama S, FEBS Lett. 2007 Feb 6;581(3):462-8. Epub 2007 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17239860 17239860] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Yokoyama, S.]] | [[Category: Yokoyama, S.]] | ||
[[Category: dimer]] | [[Category: dimer]] | ||
| - | [[Category: national project on protein structural and functional | + | [[Category: national project on protein structural and functional analyse]] |
[[Category: nppsfa]] | [[Category: nppsfa]] | ||
[[Category: riken structural genomics/proteomics initiative]] | [[Category: riken structural genomics/proteomics initiative]] | ||
[[Category: rsgi]] | [[Category: rsgi]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: ww domain]] | [[Category: ww domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:32:37 2008'' |
Revision as of 14:32, 20 March 2008
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| Gene: | Sav1, Ww45, Wwp3 (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)
Overview
The WW domain is known as one of the smallest protein modules with a triple-stranded beta-sheet fold. Here, we present the solution structure of the second WW domain from the mouse salvador homolog 1 protein. This WW domain forms a homodimer with a beta-clam-like motif, as evidenced by size exclusion chromatography, analytical ultracentrifugation and NMR spectroscopy. While typical WW domains are believed to function as monomeric modules that recognize proline-rich sequences, by using conserved aromatic and hydrophobic residues that are solvent-exposed on the surface of the beta-sheet, this WW domain buries these residues in the dimer interface.
About this Structure
2DWV is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Solution structure of an atypical WW domain in a novel beta-clam-like dimeric form., Ohnishi S, Guntert P, Koshiba S, Tomizawa T, Akasaka R, Tochio N, Sato M, Inoue M, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yokoyama S, FEBS Lett. 2007 Feb 6;581(3):462-8. Epub 2007 Jan 16. PMID:17239860
Page seeded by OCA on Thu Mar 20 16:32:37 2008
Categories: Mus musculus | Single protein | Guntert, P. | Harada, T. | Inoue, M. | Kigawa, T. | Koshiba, S. | Ohnishi, S. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Sato, M. | Tochio, N. | Tomizawa, T. | Watanabe, S. | Yokoyama, S. | Dimer | National project on protein structural and functional analyse | Nppsfa | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic | Ww domain
