3kfc

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{{STRUCTURE_3kfc| PDB=3kfc | SCENE= }}
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==Complex Structure of LXR with an agonist==
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===Complex Structure of LXR with an agonist===
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<StructureSection load='3kfc' size='340' side='right' caption='[[3kfc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19932617}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3kfc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KFC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=61X:4-{3-[3-(METHYLSULFONYL)PHENOXY]PHENYL}-8-(TRIFLUOROMETHYL)QUINOLINE'>61X</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1H2, LXRB, NER, UNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kfc RCSB], [http://www.ebi.ac.uk/pdbsum/3kfc PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/3kfc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A series of 4-(3-aryloxyaryl)quinolines with sulfone substituents on the terminal aryl ring (7) was prepared as LXR agonists. High affinity LXR ligands with excellent agonist potency and efficacy in functional assays of LXR activity were identified. In general, these sulfone agonists were equal to or superior to previously described alcohol and amide analogs in terms of affinity, functional potency, and microsomal stability. Many of the sulfones had LXRbeta binding IC(50) values &lt;10nM while the most potent compounds in an ABCA1 mRNA induction assay in J774 mouse cells had EC(50) values &lt;10nM and were as efficacious as T0901317.
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==Function==
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4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.,Bernotas RC, Singhaus RR, Kaufman DH, Travins JM, Ullrich JW, Unwalla R, Quinet E, Evans M, Nambi P, Olland A, Kauppi B, Wilhelmsson A, Goos-Nilsson A, Wrobel J Bioorg Med Chem Lett. 2010 Jan 1;20(1):209-12. Epub 2009 Oct 31. PMID:19932617<ref>PMID:19932617</ref>
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[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3kfc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019932617</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bernotas, R C.]]
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[[Category: Bernotas, R C]]
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[[Category: Olland, A.]]
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[[Category: Olland, A]]
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[[Category: Unwalla, R.]]
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[[Category: Unwalla, R]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Liver x receptor]]
[[Category: Liver x receptor]]

Revision as of 14:50, 18 December 2014

Complex Structure of LXR with an agonist

3kfc, resolution 2.40Å

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