3k7r

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{{STRUCTURE_3k7r| PDB=3k7r | SCENE= }}
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==Crystal structure of [TM][CuAtx1]3==
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===Crystal structure of [TM][CuAtx1]3===
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<StructureSection load='3k7r' size='340' side='right' caption='[[3k7r]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19965379}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3k7r]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K7R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4SM:TETRATHIOMOLYBDATE'>4SM</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATX1, N0840, YNL259C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k7r RCSB], [http://www.ebi.ac.uk/pdbsum/3k7r PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/3k7r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tetrathiomolybdate (TM) is an orally active agent for treatment of disorders of copper metabolism. Here we describe how TM inhibits proteins that regulate copper physiology. Crystallographic results reveal that the surprising stability of the drug complex with the metallochaperone Atx1 arises from formation of a sulfur-bridged copper-molybdenum cluster reminiscent of those found in molybdenum and iron sulfur proteins. Spectroscopic studies indicate that this cluster is stable in solution and corresponds to physiological clusters isolated from TM-treated Wilson's disease animal models. Finally, mechanistic studies show that the drug-metallochaperone inhibits metal transfer functions between copper-trafficking proteins. The results are consistent with a model wherein TM can directly and reversibly down-regulate copper delivery to secreted metalloenzymes and suggest that proteins involved in metal regulation might be fruitful drug targets.
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==Function==
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Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation.,Alvarez HM, Xue Y, Robinson CD, Canalizo-Hernandez MA, Marvin RG, Kelly RA, Mondragon A, Penner-Hahn JE, O'Halloran TV Science. 2010 Jan 15;327(5963):331-4. Epub 2009 Nov 26. PMID:19965379<ref>PMID:19965379</ref>
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[[http://www.uniprot.org/uniprot/ATX1_YEAST ATX1_YEAST]] Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3k7r]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7R OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019965379</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Alvarez, H M.]]
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[[Category: Alvarez, H M]]
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[[Category: Halloran, T V.O.]]
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[[Category: Halloran, T V.O]]
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[[Category: Mondragon, A.]]
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[[Category: Mondragon, A]]
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[[Category: Robinson, C D.]]
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[[Category: Robinson, C D]]
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[[Category: Xue, Y.]]
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[[Category: Xue, Y]]
[[Category: Chaperone]]
[[Category: Chaperone]]
[[Category: Copper transport]]
[[Category: Copper transport]]

Revision as of 16:42, 18 December 2014

Crystal structure of [TM][CuAtx1]3

3k7r, resolution 2.28Å

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