3k41

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Revision as of 02:27, 4 April 2013

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Template:STRUCTURE 3k41

Contents 1 Crystal structure of sCD-MPR mutant E19Q/K137M bound to Man-6-P 2 Function 3 About this Structure 4 Reference

Crystal structure of sCD-MPR mutant E19Q/K137M bound to Man-6-P

Template:ABSTRACT PUBMED 19928875

Function

[MPRD_BOVIN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

About this Structure

3k41 is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

• Olson LJ, Sun G, Bohnsack RN, Peterson FC, Dahms NM, Kim JJ. Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry. 2010 Jan 12;49(1):236-46. PMID:19928875 doi:10.1021/bi901725x