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Neurexin
From Proteopedia
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{{STRUCTURE_3bod| PDB=3bod | SIZE=400| SCENE= |right|CAPTION=Mouse neurexin 1α LNS domain with Ca+2 ion ([[3bod]]) }} | {{STRUCTURE_3bod| PDB=3bod | SIZE=400| SCENE= |right|CAPTION=Mouse neurexin 1α LNS domain with Ca+2 ion ([[3bod]]) }} | ||
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[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See [[Neurodevelopmental Disorders]]. | [[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See [[Neurodevelopmental Disorders]]. | ||
For Structural Analysis of Neurexin, See: [[Neuroligin-Neurexin Interaction]] | For Structural Analysis of Neurexin, See: [[Neuroligin-Neurexin Interaction]] | ||
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== 3D Structures of Neurexin == | == 3D Structures of Neurexin == | ||
Revision as of 08:57, 19 August 2014
Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See Neurodevelopmental Disorders.
For Structural Analysis of Neurexin, See: Neuroligin-Neurexin Interaction
3D Structures of Neurexin
Updated February 2013
NRXN
3mw2 – mNRXN-1α LNS domain+splice insert 4 – mouse
3bod, 3bop - mNRXN-1α LNS domain
3mw3, 2r1b - rNRXN-1α LNS domain+splice insert 4 – rat
2r16 - rNRXN-1α LNS domain+Ca
1c4r - rNRXN-1α LNS domain
3mw4 - mNRXN-1α LNS domain
2h0b - bNRXN-1α LNS2 domain – bovine
3asi - bNRXN-1α LNS5-EGF3-LNS6 domains
3poy - bNRXN-1α LNS2-LNS6 domains (mutant)
3qcw, 3r05 - bNRXN-1α LNS1-LNS6 domains (mutant)
2r1d - rNRXN-1β LNS/LG domain
NRXN+NLGN
2xb6, 2wqz – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain
3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain
3vkf - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain
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