3ld6

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Template:STRUCTURE 3ld6

Contents

Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole

Template:ABSTRACT PUBMED 20149798

Function

[CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

About this Structure

3ld6 is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3i3k. Full crystallographic information is available from OCA.

Reference

  • Strushkevich N, Usanov SA, Park HW. Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol. 2010 Apr 9;397(4):1067-78. Epub 2010 Feb 10. PMID:20149798 doi:10.1016/j.jmb.2010.01.075

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OCA

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