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3l4h

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Template:STRUCTURE 3l4h

Contents

Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1

Function

[HECW1_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

About this Structure

3l4h is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Proteopedia Page Contributors and Editors (what is this?)

OCA

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