3l2a

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Template:STRUCTURE 3l2a

Contents

Crystal structure of Reston Ebola VP35 interferon inhibitory domain

Template:ABSTRACT PUBMED 20399790

Function

[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).

About this Structure

3l2a is a 1 chain structure with sequence from Reston ebolavirus. Full crystallographic information is available from OCA.

Reference

  • Leung DW, Shabman RS, Farahbakhsh M, Prins KC, Borek DM, Wang T, Muhlberger E, Basler CF, Amarasinghe GK. Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain. J Mol Biol. 2010 Jun 11;399(3):347-57. Epub 2010 Apr 24. PMID:20399790 doi:10.1016/j.jmb.2010.04.022

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OCA

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