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3ld1

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{{STRUCTURE_3ld1| PDB=3ld1 | SCENE= }}
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==Crystal Structure of IBV Nsp2a==
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===Crystal Structure of IBV Nsp2a===
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<StructureSection load='3ld1' size='340' side='right' caption='[[3ld1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3ld1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LD1 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">1a, 1ab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ld1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ld1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ld1 PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[3ld1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA].
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__TOC__
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</StructureSection>
[[Category: Viruses]]
[[Category: Viruses]]
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[[Category: Bartlam, M.]]
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[[Category: Bartlam, M]]
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[[Category: Chen, C.]]
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[[Category: Chen, C]]
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[[Category: Cong, L.]]
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[[Category: Cong, L]]
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[[Category: Fu, J.]]
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[[Category: Fu, J]]
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[[Category: Rao, Z.]]
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[[Category: Rao, Z]]
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[[Category: Tang, H.]]
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[[Category: Tang, H]]
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[[Category: Wei, L.]]
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[[Category: Wei, L]]
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[[Category: Xu, Y.]]
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[[Category: Xu, Y]]
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[[Category: Yang, A.]]
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[[Category: Yang, A]]
[[Category: Globular like]]
[[Category: Globular like]]
[[Category: Host cytoplasm]]
[[Category: Host cytoplasm]]

Revision as of 17:46, 18 December 2014

Crystal Structure of IBV Nsp2a

3ld1, resolution 2.50Å

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