3l1p

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Revision as of 20:14, 4 April 2013

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Template:STRUCTURE 3l1p

Contents 1 POU protein:DNA complex 2 Function 3 About this Structure 4 Reference

POU protein:DNA complex

Function

[PO5F1_MOUSE] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.^{[1] [2]}

About this Structure

3l1p is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

1. ↑ Zhang Z, Liao B, Xu M, Jin Y. Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. FASEB J. 2007 Oct;21(12):3042-51. Epub 2007 May 11. PMID:17496161 doi:fj.06-6914com
2. ↑ Wei F, Scholer HR, Atchison ML. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem. 2007 Jul 20;282(29):21551-60. Epub 2007 May 24. PMID:17525163 doi:M611041200