1okx
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1OKX is a | + | 1OKX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Scytonema_hofmanni Scytonema hofmanni] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Structure known Active Site: SC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:31:54 2007'' |
Revision as of 11:26, 5 November 2007
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BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A
Overview
Natural bioactive compounds are of general interest to pharmaceutical, research because they may be used as leads in drug development campaigns., Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known, to inhibit porcine pancreatic elastase, which in turn resembles the, attractive drug target neutrophil elastase. The crystal structure of, scyptolin A as bound to pancreatic elastase was solved at 2.8 A, resolution. The inhibitor occupies the most prominent subsites S1 through, S4 of the elastase and prevents a hydrolytic attack by covering the active, center with its rigid ring structure. The observed binding structure may, help to design potent elastase inhibitors.
About this Structure
1OKX is a Protein complex structure of sequences from Scytonema hofmanni and Sus scrofa. Active as Pancreatic elastase, with EC number 3.4.21.36 Structure known Active Site: SC1. Full crystallographic information is available from OCA.
Reference
Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:14583266
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