3ku2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3ku2" [edit=sysop:move=sysop])
Line 1: Line 1:
-
{{STRUCTURE_3ku2| PDB=3ku2 | SCENE= }}
+
==Crystal Structure of inactivated form of CDPK1 from toxoplasma gondii, TGME49.101440==
-
===Crystal Structure of inactivated form of CDPK1 from toxoplasma gondii, TGME49.101440===
+
<StructureSection load='3ku2' size='340' side='right' caption='[[3ku2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_20436473}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3ku2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KU2 FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDPK1, TGME49_101440 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 Toxoplasma gondii])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ku2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ku2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ku2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ku2 PDBsum]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/3ku2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Calcium-dependent protein kinases (CDPKs) have pivotal roles in the calcium-signaling pathway in plants, ciliates and apicomplexan parasites and comprise a calmodulin-dependent kinase (CaMK)-like kinase domain regulated by a calcium-binding domain in the C terminus. To understand this intramolecular mechanism of activation, we solved the structures of the autoinhibited (apo) and activated (calcium-bound) conformations of CDPKs from the apicomplexan parasites Toxoplasma gondii and Cryptosporidium parvum. In the apo form, the C-terminal CDPK activation domain (CAD) resembles a calmodulin protein with an unexpected long helix in the N terminus that inhibits the kinase domain in the same manner as CaMKII. Calcium binding triggers the reorganization of the CAD into a highly intricate fold, leading to its relocation around the base of the kinase domain to a site remote from the substrate binding site. This large conformational change constitutes a distinct mechanism in calcium signal-transduction pathways.
-
==About this Structure==
+
Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.,Wernimont AK, Artz JD, Finerty P Jr, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R Nat Struct Mol Biol. 2010 May;17(5):596-601. Epub 2010 May 2. PMID:20436473<ref>PMID:20436473</ref>
-
[[3ku2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KU2 OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:020436473</ref><references group="xtra"/><references/>
+
</div>
 +
 
 +
==See Also==
 +
*[[Calcium-dependent protein kinase|Calcium-dependent protein kinase]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith, C H]]
-
[[Category: Artz, J D.]]
+
[[Category: Artz, J D]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Bochkarev, A]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra, C]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards, A M]]
-
[[Category: Finnerty, P.]]
+
[[Category: Finnerty, P]]
-
[[Category: Hassani, A A.]]
+
[[Category: Hassani, A A]]
-
[[Category: He, H.]]
+
[[Category: He, H]]
-
[[Category: Hui, R.]]
+
[[Category: Hui, R]]
-
[[Category: Lourido, S.]]
+
[[Category: Lourido, S]]
-
[[Category: Mackenzie, F.]]
+
[[Category: Mackenzie, F]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Structural genomic]]
-
[[Category: Sibley, D L.]]
+
[[Category: Sibley, D L]]
-
[[Category: Sinestera, G.]]
+
[[Category: Sinestera, G]]
-
[[Category: Vedadi, M.]]
+
[[Category: Vedadi, M]]
-
[[Category: Wasney, G.]]
+
[[Category: Wasney, G]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt, J]]
-
[[Category: Wernimont, A K.]]
+
[[Category: Wernimont, A K]]
-
[[Category: Xiao, T.]]
+
[[Category: Xiao, T]]
-
[[Category: Y H., Lin.]]
+
[[Category: Y H., Lin]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Cdpk]]
[[Category: Cdpk]]
Line 35: Line 59:
[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Sgc]]
[[Category: Sgc]]
-
[[Category: Structural genomic]]
 
-
[[Category: Structural genomics consortium]]
 
[[Category: Toxoplasma]]
[[Category: Toxoplasma]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 17:53, 18 December 2014

Crystal Structure of inactivated form of CDPK1 from toxoplasma gondii, TGME49.101440

3ku2, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ku2"
Personal tools