3lcu

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Template:STRUCTURE 3lcu

Contents

Crystal Structure of Antibiotic related Methyltransferase

Template:ABSTRACT PUBMED 20194115

Function

[Q7M0R2_9ACTO] Specifically methylates the N(7) position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides, including gentamicin, kanamycin and sisomicin.[1] [2]

About this Structure

3lcu is a 1 chain structure with sequence from Micromonospora zionensis. Full crystallographic information is available from OCA.

Reference

  • Husain N, Tkaczuk KL, Tulsidas SR, Kaminska KH, Cubrilo S, Maravic-Vlahovicek G, Bujnicki JM, Sivaraman J. Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. Nucleic Acids Res. 2010 Jul 1;38(12):4120-32. Epub 2010 Mar 1. PMID:20194115 doi:10.1093/nar/gkq122
  1. ↑ Kojic M, Topisirovic L, Vasiljevic B. Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zionensis. J Bacteriol. 1992 Dec;174(23):7868-72. PMID:1447159
  2. ↑ Savic M, Lovric J, Tomic TI, Vasiljevic B, Conn GL. Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics. Nucleic Acids Res. 2009 Sep;37(16):5420-31. doi: 10.1093/nar/gkp575. Epub 2009, Jul 9. PMID:19589804 doi:10.1093/nar/gkp575

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OCA

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