4b0f
From Proteopedia
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| - | + | ==Heptameric core complex structure of C4b-binding (C4BP) protein from human== | |
| - | + | <StructureSection load='4b0f' size='340' side='right' caption='[[4b0f]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4b0f]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B0F FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a55|2a55]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b0f RCSB], [http://www.ebi.ac.uk/pdbsum/4b0f PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The complement system as major part of innate immunity is the first line of defense against invading microorganisms. Orchestrated by more than 60 proteins, its major task is to discriminate between host cells and pathogens and to initiate immune response. Additional recognition of necrotic or apoptotic cells demand a fine-tune regulation of this powerful system. C4b-binding protein (C4BP) is the major inhibitor of the classical complement and lectin pathway. The crystal structure of the human C4BP oligomerization domain in its 7alpha isoform and molecular simulations provide first structural insights of C4BP oligomerization. The heptameric core structure is stabilized by intermolecular disulfide bonds. In addition, thermal shift assays indicate that layers of electrostatic interactions mainly contribute to the extraordinary thermodynamic stability of the complex. These findings make C4BP a promising scaffold for multivalent ligand display with applications in immunology and biological chemistry. | ||
| - | + | Arranged sevenfold: structural insights into the C-terminal oligomerization domain of human C4b-binding protein.,Hofmeyer T, Schmelz S, Degiacomi MT, Peraro MD, Daneschdar M, Scrima A, den Heuvel JV, Heinz DW, Kolmar H J Mol Biol. 2012 Dec 27. pii: S0022-2836(12)00950-3. doi:, 10.1016/j.jmb.2012.12.017. PMID:23274142<ref>PMID:23274142</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Heinz, D W | + | [[Category: Heinz, D W]] |
| - | [[Category: Hofmeyer, T | + | [[Category: Hofmeyer, T]] |
| - | [[Category: Kolmar, H | + | [[Category: Kolmar, H]] |
| - | [[Category: Schmelz, S | + | [[Category: Schmelz, S]] |
[[Category: Complement system]] | [[Category: Complement system]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
Revision as of 09:13, 21 December 2014
Heptameric core complex structure of C4b-binding (C4BP) protein from human
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