3mex

From Proteopedia

Revision as of 23:02, 10 April 2013 (edit) OCA (Talk | contribs) ← Previous diff

Revision as of 23:02, 10 April 2013 (edit) (undo) OCA (Talk | contribs) m (Protected "3mex" [edit=sysop:move=sysop]) Next diff →

---

Revision as of 23:02, 10 April 2013

proteopedia linkproteopedia link

Template:STRUCTURE 3mex

Contents 1 Crystal structure of MexR in oxidized state 2 Function 3 About this Structure 4 Reference

Crystal structure of MexR in oxidized state

Template:ABSTRACT PUBMED 20616806

Function

[MEXR_PSEAE] Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.

About this Structure

3mex is a 2 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

• Chen H, Yi C, Zhang J, Zhang W, Ge Z, Yang CG, He C. Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR. EMBO Rep. 2010 Sep;11(9):685-90. Epub 2010 Jul 9. PMID:20616806 doi:10.1038/embor.2010.96