3mex
From Proteopedia
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| - | + | ==Crystal structure of MexR in oxidized state== | |
| - | === | + | <StructureSection load='3mex' size='340' side='right' caption='[[3mex]], [[Resolution|resolution]] 2.10Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3mex]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MEX FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lnw|1lnw]], [[3ech|3ech]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MEXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mex RCSB], [http://www.ebi.ac.uk/pdbsum/3mex PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/3mex_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | MexR functions as the primary regulator of the mexAB-oprM multidrug efflux expression in Pseudomonas aeruginosa. It has been shown that MexR senses oxidative stress by interprotomer disulphide bond formation between redox-active cysteines. This oxidation induces MexR to dissociate from the promoter DNA, thus activating the transcriptional expression of efflux pump genes. In this study, we present the crystal structure of MexR in its oxidized form at a resolution of 2.1 A. This crystal structure reveals the mechanism by which oxidative signal allosterically derepresses the MexR-controlled transcription activation. | ||
| - | + | Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR.,Chen H, Yi C, Zhang J, Zhang W, Ge Z, Yang CG, He C EMBO Rep. 2010 Sep;11(9):685-90. Epub 2010 Jul 9. PMID:20616806<ref>PMID:20616806</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
| - | [[Category: Chen, H | + | [[Category: Chen, H]] |
| - | [[Category: He, C | + | [[Category: He, C]] |
| - | [[Category: Yang, C G | + | [[Category: Yang, C G]] |
| - | [[Category: Yi, C | + | [[Category: Yi, C]] |
| - | [[Category: Zhang, J | + | [[Category: Zhang, J]] |
| - | [[Category: Zhang, W | + | [[Category: Zhang, W]] |
[[Category: Antibiotics resistance regulation]] | [[Category: Antibiotics resistance regulation]] | ||
[[Category: Dna-binding]] | [[Category: Dna-binding]] | ||
Revision as of 15:12, 18 December 2014
Crystal structure of MexR in oxidized state
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