3lpv

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{{STRUCTURE_3lpv| PDB=3lpv | SCENE= }}
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==X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link==
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===X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link===
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<StructureSection load='3lpv' size='340' side='right' caption='[[3lpv]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20541266}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lpv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LPV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aio|1aio]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lpv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lpv RCSB], [http://www.ebi.ac.uk/pdbsum/3lpv PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the 1.77-A resolution X-ray crystal structure of a dodecamer DNA duplex with the sequence 5'-CCTCTGGTCTCC-3' that has been modified to contain a single engineered 1,2-cis-{Pt(NH(3))(2)}(2+)-d(GpG) cross-link, the major DNA adduct of cisplatin. These data represent a significant improvement in resolution over the previously published 2.6-A structure. The ammine ligands in this structure are clearly resolved, leading to improved visualization of the cross-link geometry with respect to both the platinum center and to the nucleobases, which adopt a higher energy conformation. Also better resolved are the deoxyribose sugar puckers, which allow us to re-examine the global structure of platinum-modified DNA. Another new feature of this model is the location of four octahedral [Mg(H(2)O)(6)](2+) ions associated with bases in the DNA major groove and the identification of 124 ordered water molecules that participate in hydrogen-bonding interactions with either the nucleic acid or the diammineplatinum(II) moiety.
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==About this Structure==
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Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH3)2}2+-d(GpG) cross-link at 1.77 A resolution.,Todd RC, Lippard SJ J Inorg Biochem. 2010 Sep;104(9):902-8. Epub 2010 Apr 18. PMID:20541266<ref>PMID:20541266</ref>
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[[3lpv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPV OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020541266</ref><references group="xtra"/><references/>
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</div>
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[[Category: Lippard, S J.]]
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== References ==
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[[Category: Todd, R C.]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Lippard, S J]]
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[[Category: Todd, R C]]
[[Category: Cisplatin]]
[[Category: Cisplatin]]
[[Category: Dna]]
[[Category: Dna]]

Revision as of 16:36, 18 December 2014

X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link

3lpv, resolution 1.77Å

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