3m1h
From Proteopedia
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{{STRUCTURE_3m1h| PDB=3m1h | SCENE= }} | {{STRUCTURE_3m1h| PDB=3m1h | SCENE= }} | ||
===Crystal Structure Analysis of the K3 Cleaved Adhesin Domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis w83=== | ===Crystal Structure Analysis of the K3 Cleaved Adhesin Domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis w83=== | ||
| - | {{ | + | {{ABSTRACT_PUBMED_21812842}} |
==Function== | ==Function== | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/KGP83_PORGN KGP83_PORGN]] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2] |
==About this Structure== | ==About this Structure== | ||
| - | [[3m1h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3m1h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Porphyromonas_gingivalis_w83 Porphyromonas gingivalis w83]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M1H OCA]. |
| - | [[Category: Porphyromonas gingivalis]] | + | |
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021812842</ref><references group="xtra"/><references/> | ||
| + | [[Category: Porphyromonas gingivalis w83]] | ||
[[Category: Collyer, C A.]] | [[Category: Collyer, C A.]] | ||
[[Category: Hunter, N.]] | [[Category: Hunter, N.]] | ||
Revision as of 02:50, 20 September 2013
Contents |
Crystal Structure Analysis of the K3 Cleaved Adhesin Domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis w83
Template:ABSTRACT PUBMED 21812842
Function
[KGP83_PORGN] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]
About this Structure
3m1h is a 4 chain structure with sequence from Porphyromonas gingivalis w83. Full crystallographic information is available from OCA.
Reference
- Li N, Yun P, Jeffries CM, Langley D, Gamsjaeger R, Church WB, Hunter N, Collyer CA. The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis. Mol Microbiol. 2011 Sep;81(5):1358-73. doi: 10.1111/j.1365-2958.2011.07768.x., Epub 2011 Aug 4. PMID:21812842 doi:10.1111/j.1365-2958.2011.07768.x
