3mca

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Revision as of 23:18, 10 April 2013

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Template:STRUCTURE 3mca

Contents 1 Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay 2 Function 3 About this Structure 4 Reference

Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay

Template:ABSTRACT PUBMED 20890290

Function

[HBS1_SCHPO] Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs (By similarity).[UniProtKB:P32769] [DOM34_SCHPO] Involved in protein translation. Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of hbs1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions (By similarity).[UniProtKB:P33309]

About this Structure

3mca is a 2 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

• Chen L, Muhlrad D, Hauryliuk V, Cheng Z, Lim MK, Shyp V, Parker R, Song H. Structure of the Dom34-Hbs1 complex and implications for no-go decay. Nat Struct Mol Biol. 2010 Oct;17(10):1233-40. Epub 2010 Oct 3. PMID:20890290 doi:10.1038/nsmb.1922