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3lpz
From Proteopedia
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| - | + | ==Crystal structure of C. therm. Get4== | |
| - | === | + | <StructureSection load='3lpz' size='340' side='right' caption='[[3lpz]], [[Resolution|resolution]] 1.98Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3lpz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LPZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iqw|3iqw]], [[3iqx|3iqx]], [[2wpv|2wpv]], [[3lku|3lku]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Get4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 Chaetomium thermophilum])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lpz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lpz RCSB], [http://www.ebi.ac.uk/pdbsum/3lpz PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lp/3lpz_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tail-anchored proteins play important roles in protein translocation, membrane fusion and apoptosis. They are targeted to the endoplasmic reticulum membrane via the guided-entry of tail-anchored proteins (Get) pathway. We present the 2A crystal structure of Get4 which participates in early steps of the Get pathway. The structure shows an alpha-solenoid fold with particular deviations from the regular pairwise arrangement of alpha-helices. A conserved hydrophobic groove accommodates the flexible C-terminal region in trans. The structural organization of the Get4 helical hairpin motifs provides a scaffold for protein-protein interactions in the Get pathway. | ||
| - | + | The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis.,Bozkurt G, Wild K, Amlacher S, Hurt E, Dobberstein B, Sinning I FEBS Lett. 2010 Apr 16;584(8):1509-14. Epub 2010 Mar 3. PMID:20206626<ref>PMID:20206626</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Chaetomium thermophilum]] | [[Category: Chaetomium thermophilum]] | ||
| - | [[Category: Bozkurt, G | + | [[Category: Bozkurt, G]] |
| - | [[Category: Sinning, I | + | [[Category: Sinning, I]] |
| - | [[Category: Wild, K | + | [[Category: Wild, K]] |
[[Category: Get pathway]] | [[Category: Get pathway]] | ||
[[Category: Get5 binding]] | [[Category: Get5 binding]] | ||
Revision as of 17:56, 18 December 2014
Crystal structure of C. therm. Get4
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