3m4w

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{{STRUCTURE_3m4w| PDB=3m4w | SCENE= }}
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==Structural basis for the negative regulation of bacterial stress response by RseB==
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===Structural basis for the negative regulation of bacterial stress response by RseB===
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<StructureSection load='3m4w' size='340' side='right' caption='[[3m4w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20512978}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m4w]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M4W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2p4b|2p4b]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RseB (Amino Acids 24-318) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), RseA (Amino Acids 121-216) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m4w RCSB], [http://www.ebi.ac.uk/pdbsum/3m4w PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/3m4w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sigmaE-dependent stress response in bacterial cells is initiated by the DegS- and RseP-regulated intramembrane proteolysis of a membrane-spanning antisigma factor, RseA. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. In the crystal structure of the periplasmic domain of RseA bound to RseB, the DegS cleavage site of RseA is unstructured, however, its P1 residue is buried in the hydrophobic pocket of RseB, which suggests that RseB binding blocks the access of DegS to the cleavage site.
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==Function==
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Structural basis for the negative regulation of bacterial stress response by RseB.,Kim DY, Kwon E, Choi J, Hwang HY, Kim KK Protein Sci. 2010 Jun;19(6):1258-63. PMID:20512978<ref>PMID:20512978</ref>
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[[http://www.uniprot.org/uniprot/RSEB_ECOLI RSEB_ECOLI]] Seems to modulate the activity of RpoE (sigma-E). [[http://www.uniprot.org/uniprot/RSEA_ECOLI RSEA_ECOLI]] Negative regulator of RpoE.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3m4w]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4W OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020512978</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Choi, J K.]]
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[[Category: Choi, J K]]
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[[Category: Hwang, H Y.]]
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[[Category: Hwang, H Y]]
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[[Category: Kim, D Y.]]
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[[Category: Kim, D Y]]
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[[Category: Kim, K K.]]
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[[Category: Kim, K K]]
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[[Category: Kwon, E.]]
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[[Category: Kwon, E]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
[[Category: Rsea]]
[[Category: Rsea]]

Revision as of 15:03, 18 December 2014

Structural basis for the negative regulation of bacterial stress response by RseB

3m4w, resolution 2.30Å

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