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3m45

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Template:STRUCTURE 3m45

Contents

Crystal structure of Ig1 domain of mouse SynCAM 2

Template:ABSTRACT PUBMED 20739279

Function

[CADM2_MOUSE] Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity).

About this Structure

3m45 is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Fogel AI, Li Y, Giza J, Wang Q, Lam TT, Modis Y, Biederer T. N-glycosylation at the SynCAM immunoglobulin interface modulates synaptic adhesion. J Biol Chem. 2010 Aug 25. PMID:20739279 doi:10.1074/jbc.M110.120865

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OCA

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