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3mc2

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Template:STRUCTURE 3mc2

Contents

Crystal Structure of the Murine Inhibitor of Carbonic Anhydrase

Template:ABSTRACT PUBMED 20572014

Function

[Q9DBD0_MOUSE] Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions.[1] [2]

About this Structure

3mc2 is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Eckenroth BE, Mason AB, McDevitt ME, Lambert LA, Everse SJ. The structure and evolution of the murine inhibitor of carbonic anhydrase: A member of the transferrin superfamily. Protein Sci. 2010 Jun 23. PMID:20572014 doi:10.1002/pro.439
  1. ↑ Wang F, Lothrop AP, James NG, Griffiths TA, Lambert LA, Leverence R, Kaltashov IA, Andrews NC, MacGillivray RT, Mason AB. A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. Biochem J. 2007 Aug 15;406(1):85-95. PMID:17511619 doi:10.1042/BJ20070384
  2. ↑ Mason AB, Judson GL, Bravo MC, Edelstein A, Byrne SL, James NG, Roush ED, Fierke CA, Bobst CE, Kaltashov IA, Daughtery MA. Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis. Biochemistry. 2008 Sep 16;47(37):9847-55. doi: 10.1021/bi801133d. Epub 2008 Aug, 20. PMID:18712936 doi:10.1021/bi801133d

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OCA

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