4ibx
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
[[4ibx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBX OCA]. | [[4ibx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBX OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023542341</ref><references group="xtra"/><references/> | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
Revision as of 04:37, 18 July 2013
Contents |
Crystal structure of stabilized TEM-1 beta-lactamase variant v.13
Template:ABSTRACT PUBMED 23542341
Function
[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
About this Structure
4ibx is a 5 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Dellus-Gur E, Toth-Petroczy A, Elias M, Tawfik DS. What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs. J Mol Biol. 2013 Mar 28. pii: S0022-2836(13)00200-3. doi:, 10.1016/j.jmb.2013.03.033. PMID:23542341 doi:10.1016/j.jmb.2013.03.033
